---

  title: "Global Meta-analysis"
  output:
    html_document:
      toc: false
      toc_float: false
      code_folding: hide
      number_sections: true
      theme: spacelab
  ---
  ## MA_HC_Excitadoras_F {.tabset .tabset-pills -}
  
  
  ```r
  library(dplyr)
  library(knitr)
  library(DT)
  library(ggplot2)
  library(plotly)
  load("/clinicfs/projects/i63/tfm_hipocampo/Metaanalysis_HC/HC/Excitadoras/F/MA_HC_Excitadoras_F.RData")
  ```

  ### MA results (significant genes) {-}  

datatable(sig.genes.df[,c(1:5,12,15)], caption='Statistics of 1588 significant genes',rownames=FALSE, escape = FALSE, filter = 'top')

MA results (volcano plot)

ggplotly(volcano_plot)

Individual results (summary)

kable(table_sum, col.names = c('Study','All genes','Significant genes'))

Study	All genes	Significant genes
Study43	11135	6391
GSE163577	21025	361
syn52293442_hc	18543	4543

sessionInfo

date()

## [1] "Sun May 25 16:04:11 2025"

sessionInfo()

## R version 4.2.2 (2022-10-31)
## Platform: x86_64-pc-linux-gnu (64-bit)
## Running under: CentOS Linux 7 (Core)
## 
## Matrix products: default
## BLAS/LAPACK: /opt/sci-soft/software/FlexiBLAS/3.0.4-GCC-11.2.0/lib64/libflexiblas.so.3.0
## 
## locale:
##  [1] LC_CTYPE=en_US.UTF-8       LC_NUMERIC=C               LC_TIME=en_US.UTF-8        LC_COLLATE=en_US.UTF-8    
##  [5] LC_MONETARY=en_US.UTF-8    LC_MESSAGES=en_US.UTF-8    LC_PAPER=en_US.UTF-8       LC_NAME=C                 
##  [9] LC_ADDRESS=C               LC_TELEPHONE=C             LC_MEASUREMENT=en_US.UTF-8 LC_IDENTIFICATION=C       
## 
## attached base packages:
## [1] stats     graphics  grDevices utils     datasets  methods   base     
## 
## other attached packages:
##  [1] plotly_4.10.4       DT_0.26             knitr_1.41          ggplot2_3.5.2       dplyr_1.0.10        limma_3.54.0       
##  [7] tibble_3.1.8        metafor_3.8-1       metadat_1.2-0       Matrix_1.5-3        Biobase_2.58.0      BiocGenerics_0.44.0
## 
## loaded via a namespace (and not attached):
##  [1] tidyselect_1.2.0   xfun_0.35          bslib_0.4.2        purrr_0.3.5        lattice_0.20-45    vctrs_0.6.5       
##  [7] generics_0.1.3     htmltools_0.5.4    viridisLite_0.4.1  yaml_2.3.6         utf8_1.2.2         rlang_1.1.6       
## [13] pillar_1.8.1       jquerylib_0.1.4    glue_1.6.2         withr_2.5.0        DBI_1.1.3          RColorBrewer_1.1-3
## [19] lifecycle_1.0.3    stringr_1.5.0      gtable_0.3.1       htmlwidgets_1.6.0  evaluate_0.19      labeling_0.4.2    
## [25] fastmap_1.1.0      crosstalk_1.2.0    fansi_1.0.3        highr_0.9          scales_1.4.0       cachem_1.0.6      
## [31] jsonlite_1.8.4     farver_2.1.1       png_0.1-8          digest_0.6.31      stringi_1.7.8      grid_4.2.2        
## [37] mathjaxr_1.6-0     cli_3.4.1          tools_4.2.2        magrittr_2.0.3     sass_0.4.4         lazyeval_0.2.2    
## [43] dichromat_2.0-0.1  tidyr_1.2.1        pkgconfig_2.0.3    ellipsis_0.3.2     data.table_1.14.6  assertthat_0.2.1  
## [49] rmarkdown_2.19     httr_1.4.4         rstudioapi_0.14    R6_2.5.1           nlme_3.1-161       compiler_4.2.2